Education and research experience:
2016 – 2021. MSc, Novosibirsk State University (NSU), Novosibirsk, Russia
04.06.2018 – 01.08.2018 Stuart L. Schreiber group. Project title "Synthesis of the DNA-encoded library scaffolds. Understanding the decarboxylative cross-coupling reactions mechanisms and stereoselectivity". The Scripps Research Institute, La Jolla, CA, USA.
01.08.2016 – 18.08.2016. Cristina Pujades group. Project title "Neurogenesis regulation in the posterior embryonic brain". School of Molecular and Theoretical Biology, Inc., Barcelona, Spain.
2021– to present. PhD student, Zelinsky Institute of Organic Chemistry RAS, Moscow, Russia.
Research interests:
medicinal chemistry, molecular design, chemical synthesis, polyfluorinated compounds, mechanistic studies, dynamic catalysis.
Member of the Mendeleev Russian Chemical Society since 2017.
Publications:
[1] Kolesnikov, A.E., Egorova, K.S., Ananikov, V.P., 2025. Integrated toxicity assessment of complex chemical mixtures in catalytic reactions. J. Hazard. Mater. 490, 137784. https://doi.org/10.1016/j.jhazmat.2025.137784.
[2] Kolesnikov, A.E., Grebennikov, N.O., Romanenko, K.A., Egorova, K.S., Ananikov, V.P., 2025. Tox-Scapes: A visual and quantitative tool for selecting safer chemical reactions by means of cytotoxicity assessment. J. Clean. Prod. 519, 145970. https://doi.org/10.1016/j.jclepro.2025.145970.
[3] Kolesnikov, A.E., Tikhomirov, A.D., Strukova, E.N., Egorova, K.S., Ananikov, V.P., 2025. Antimicrobial activity / cytotoxicity trade-offs in ionic liquids: Optimizing the balance via structural variations. J. Mol. Liq. 432, 127843. https://doi.org/10.1016/j.molliq.2025.127843.
[4] Egorova, K.S., Kolesnikov, A.E., Tikhomirov, A.D., Filippov, A.A., Ananikov, V.P., 2025. What do we learn when we study cytotoxicity? Critical shortcomings in Green Chemistry context using imidazolium ionic liquids as a case example. Green Chem. 27 (26), 7863-7877. https://doi.org/10.1039/d5gc00836k.
[5] Egorova, K.S., Kolesnikov, A.E., Posvyatenko, A.V., Galushko, A.S., Shaydullin, R.R., Ananikov, V.P., 2024. Establishing the main determinants of the environmental safety of catalytic fine chemical synthesis with catalytic cross-coupling reactions. Green Chem. 26 (5), 2825-2841. https://doi.org/10.1039/d3gc04572b.
[6] Pankov, R., Khanipova, A., Son, A., Prima, D., Kolesnikov, A., Ivanova, N., Fakhrutdinov, A., Minyaev, M., Ananikov, V.P., 2025. Hybrid tuning in NHC ligands: Synergistic effects of BIAN ?-conjugation and aryl ?-modulation in gold(I) complexes. Chem. Eur. J., e202501647. https://doi.org/10.1002/chem.202501647.
[7] Chernavin, P., Letyagin, G., Tolstikov, S., Kolesnikov, A., Romanenko, G., Smirnova, K., Borodulina, A., Ovcharenko, V., Bogomyakov, A., 2024. Pyridyl-substituted nitronyl nitroxides: Comprehensive magnetochemical and quantum chemical study. Chem. Eur. J. 30 (46), e202400873. https://doi.org/10.1002/chem.202400873.
[8] Boichenko, D.S., Kolomoets, N.I., Boiko, D.A., Galushko, A.S., Posvyatenko, A.V., Kolesnikov, A.E., Egorova, K.S., Ananikov, V.P., 2024. Build-a-Bio-Strip: An online platform for rapid toxicity assessment in chemical synthesis. J. Chem. Inf. Model. 64 (22), 8373-8378. https://doi.org/10.1021/acs.jcim.4c01381.
[9] Kolesnikov, A.E., Bryzgalov, A.O., Tolstikov, S.E., Yanshole, V.V., Romanenko, G.V., Letyagin, G.A., Smirnova, K.A., Tolstikova, T.G., Bogomyakov, A.S., Ovcharenko, V.I., 2024. Novel pyridyl-substituted nitronyl nitroxides as potential antiarrhythmic and hypotensive agents with low toxicity and enhanced stability in aqueous solutions. Nitric Oxide 143, 9-15. https://doi.org/10.1016/j.niox.2023.12.001.
[10] Tolstikov, S.E., Kolesnikov, A.E., Smirnova, K.A., Letyagin, G.A., Bogomyakov, A.S., Romanenko, G.V., Ovcharenko, V.I., 2025. Heterospin molecular complexes of Cu(hfac)2 with pyridyl-substituted nitronyl nitroxides: peculiarities of structure and magnetic properties. New J. Chem. 49 (18), 7655-7660. https://doi.org/10.1039/d5nj00967g.
[11] Egorova, K.S., Posvyatenko, A.V., Galushko, A.S., Kolesnikov, A.E., 2024. Comparison of assessments of overall toxicity of chemical reactions upon using cytotoxicity and acute toxicity data. Mendeleev Commun. 34 (3), 351-353. https://doi.org/10.1016/j.mencom.2024.04.013.
[12] Egorova, K.S., Posvyatenko, A.V., Galushko, A.S., Kolesnikov, A.E., 2024. Assessing the contribution of reaction components to the overall toxicity of synthesis of 4-methoxy-4'-nitro-1,1'-biphenyl. Mendeleev Commun. 34 (2), 181-184. https://doi.org/10.1016/j.mencom.2024.02.007.
[13] Kolesnikov, A.E., Egorova, K.S., 2024. Evaluation of toxicity of ionic liquids as solvents in C–C cross-coupling reaction. Doklady Chem. 514 (2), 50-57. https://doi.org/10.1134/s0012500824600068.
[14] Tolstikov, S., Smirnova, K., Kolesnikov, A., Letyagin, G., Bogomyakov, A., Romanenko, G., Ovcharenko, V., 2023. Relationship between phase transition temperature and accessible volume for substituent in Cu(hfac)2 chain-polymer complexes with pyridine-based nitroxides. Polyhedron 230, 116212. https://doi.org/10.1016/j.poly.2022.116212.
[15] Prima, D.O., Makarov, A.G., Bagryanskaya, I.Y., Kolesnikov, A.E., Zargarova, L.V., Baev, D.S., Eliseeva, T.F., Politanskaya, L.V., Makarov, A.Y., Slizhov, Y.G., Zibarev, A.V., 2019. Fluorine?containing n?6?and angular and linear n?6?n' (n, n' = 5, 6, 7) diaza?heterocyclic scaffolds assembled on benzene core in unified way. ChemistrySelect 4 (8), 2383-2386. https://doi.org/10.1002/slct.201803970.
