21 September 2021

The dawn of cross-coupling

Methods for the direct one-step replacement of a hydrogen atom in a C–H bond by an organic functional group can create enormous possibilities for synthetic applications. On the way to solve this challenge, the discovery of the reaction of organopalladium complexes with olefins opened a new era in catalysis and organic chemistry.

Reference: Nature Catalysis, 2021, 9, 8, 3011-3042

DOI: 10.1038/s41929-021-00675-1