Education and professional experience
2001-2006 - Department of Molecular Biology, Faculty of Biology, M.V. Lomonosov Moscow State University, Russian Federation.
2003-2005 – training in the Laboratory of molecular developmental biology, V.A. Engelhardt Institute of Molecular Biology RAS.
2005-2006 – training (diploma project) in the Dr. Ryazanov's group in the Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, USA.
2006-2009 - PhD student in the Department of Molecular Genetics of Cell, Institute of Molecular Genetics RAS; PhD in molecular biology.
2009-2011 - junior researcher in the Department of Molecular Genetics of Cell, Institute of Molecular Genetics RAS.
2012 – present - researcher (from 2017 - senior researcher) in the Laboratory of metal-complex and nano-scale catalysts, N.D. Zelinsky Institute of Organic Chemistry RAS; Dr.Chem.Sci (bioorganic chemistry).
Research interests:
Carbohysrate databases, biological activity of ionic liquids, cytotoxicity of transition metals
Publications:
1. Shevelyov YY, Lavrov SA, Mikhaylova LM, Nurminsky ID, Kulathinal RJ, Egorova KS, Rozovsky YM, Nurminsky DI. The B-type lamin is required for somatic repression of testis-specific gene clusters. PNAS 2009, 106(9):3282-3287. doi: 10.1073/pnas.0811933106
2. Egorova KS, Olenkina OM, Kibanov MV, Kalmykova AI, Gvozdev VA, Olenina LV. Genetically derepressed nucleoplasmic Stellate protein in spermatocytes of D. melanogaster interacts with the catalytic subunit of protein kinase 2 and carries histone-like lysine-methylated mark. J. Mol. Biol. 2009, 389(5): 895-906. doi: 10.1016/j.jmb.2009.04.064
3. К.С. Егорова, О.М. Оленкина, Л.В. Оленина. Метилирование негистоновых белков по остаткам лизина как способ регуляции их стабильности и функциональности. Биохимия 2010, 75(5): 613-628 // Egorova KS, Olenkina OM, and Olenina LV. Lysine methylation on nonhistone proteins is a way to regulate their stability and function. Biochemistry (Moscow) 2010, 75(5): 535-548. doi: 10.1134/S0006297910050019
4. Kibanov MV, Egorova KS, Ryazansky SS, Sokolova OA, Kotov AA, Olenkina OM, Stolyarenko AD, Gvozdev VA, and Olenina LV. A novel organelle, the piNG-body, in the nuage of Drosophila male germ cells, is associated with piRNA-mediated gene silencing. Mol. Biol. Cell 2011, 22(18): 3410-3419. doi: 10.1091/mbc.E11-02-0168
5. Egorova KS, Olenkina OM, and Olenina LV. Significance of Stellate genes in spermatogenesis of Drosophila melanogaster. In: Drosophila melanogaster: life cycle, genetics and development, Nova Science Publishers Inc, 2012.
6. Olenkina OM, Egorova KS, Kibanov MV, Gervaziev YV, Gvozdev VA, and Olenina LV. Promoter contribution to the testis-specific expression of Stellate gene family in Drosophila melanogaster. Gene 2012, 499(1): 143-153. doi: 10.1016/j.gene.2012.03.023
7. О.М. Оленкина, К.С. Егорова, А.А. Аравин, Н.М. Наумова, В.А. Гвоздев, Л.В. Оленина. Картирование цис-регуляторных участков в промоторе семенник-специфичных генов Stellate у Drosophila melanogaster. Биохимия 2012, 77(11): 1536-1545 // Olenkina OM, Egorova KS, Aravin AA, Naumova NM, Gvozdev VA, and Olenina LV. Mapping of cis-regulatory sites in the promoter of testis-specific Stellate genes of Drosophila melanogaster. Biochemistry (Moscow) 2012, 77(11): 1285-1293. doi: 10.1134/S0006297912110077
8. Egorova KS and Toukach PV. Critical analysis of CCSD data quality. J. Chem. Inf. Model. 2012, 52(11): 2812-2814. doi: 10.1021/ci3002815
9. Egorova KS and Toukach PV. Expansion of coverage of Carbohydrate Structure Database (CSDB). Carb. Res. 2014, 389: 112-114. doi: 10.1016/j.carres.2013.10.009
10. Egorova KS and Ananikov VP. Toxicity of ionic liquids: eco(cyto)activity as complicated, but unavoidable parameter for task-specific optimization. ChemSusChem 2014, 7: 336-360. doi: 10.1002/cssc.201300459
11. Seitkalieva MM, Grachev AA, Egorova KS, and Ananikov VP. Nanoscale organization of ionic liquids and their interaction with peptides probed by 13C NMR spectroscopy. Tetrahedron 2014, 70(36): 6075-6081. doi: 10.1016/j.tet.2014.02.025
12. Kapaev RR, Egorova KS, and Toukach PV. Carbohydrate structure generalization scheme for database-driven simulation of experimental observables, such as NMR chemical shifts. J. Chem. Inf. Model. 2014, 54(9): 2594-2611. doi: 10.1021/ci500267u
13. Toukach PV and Egorova KS. Bacterial, Plant, and Fungal Carbohydrate Structure Database (CSDB). In: Glycoscience: Biology and Medicine, Springer-Japan, 2014, pp. 241–250. doi: 10.1007/978-4-431-54836-2_24-1, ISBN: 978-4-431-54836-2
14. Egorova KS, Seitkalieva MM, Posvyatenko AV, and Ananikov VP. An unexpected increase of toxicity of amino acid-containing ionic liquids. Toxicol. Res. 2015, 4: 152–159. doi: 10.1039/C4TX00079J
15.Seitkalieva MM, Kachala VV, Egorova KS, and Ananikov VP. Molecular extraction of peptides in ionic liquid systems. ACS Sustainable Chem. Eng. 2015, 3(2): 357–364. doi: 10.1021/sc500770v
16.Toukach PV and Egorova KS. Bacterial, Plant, and Fungal Carbohydrate Structure Databases: Daily Usage. In: Glycoinformatics, Springer – New York, 2015, pp. 55-85. doi: 10.1007/978-1-4939-2343-4_5, ISBN: 978-1-4939-2343-4
17. К.С. Егорова, Н.А. Калинчук, Ю.А. Книрель, Ф.В. Тоукач. База данных природных углеводов (CSDB) – новые возможности. Известия Академии наук, серия химическая 2015, №5, 1205-1210. // Egorova KS, Kalinchuk NA, Knirel YuA, Toukach PV. Carbohydrate Structure Database: new features. Russian Chemical Bulletin 2015, 64(5): 1205-1210. doi: 10.1007/s11172-015-1003-6
18. Toukach PV and Egorova K. Carbohydrate Structure Database merged form bacterial, plant and fungal parts. Glycoconjugate Journal 2015, 32(5): 241-242. https://link.springer.com/article/10.1007/s10719-015-9596-4
19. Egorova KS, Kondakova AN, and Toukach PV. Carbohydrate Structure Database: tools for statistical analysis of bacterial, plant and fungal glycomes. Database 2015, bav073. doi: 10.1093/database/bav073, https://academic.oup.com/database/article-lookup/doi/10.1093/database/bav073
20. Egorova KS, Seitkalieva MM, Posvyatenko AV, Khrustalev VN, and Ananikov VP. Cytotoxic activity of salicylic acid-containing drug models with ionic and covalent binding. ACS Med. Chem. Lett. 2015, 6(11): 1099-1104. doi: 10.1021/acsmedchemlett.5b00258
21. Toukach PV and Egorova KS. Carbohydrate structure database merged from bacterial, archaeal, plant and fungal parts. Nucleic Acids Res. 2016, 44(D1): D1229-D1236. doi: 10.1093/nar/gkv840
22. Egorova KS and Ananikov VP. Which metals are green for catalysis? Comparison of the toxicities of Ni, Cu, Fe, Pd, Pt, Rh, and Au salts. Angew. Chem. Int. Ed. 2016, 55(40): 12150-12162. doi: 10.1002/anie.201603777
23. Egorova KS and Toukach PV. CSDB_GT: a new curated database on glycosyltransferases. Glycobiology 2017, 27(4): 285-290. doi: 10.1093/glycob/cww137
24. Egorova KS and Toukach PV. Carbohydrate Structure Database (CSDB): Examples of Usage. In: A Practical Guide to Using Glycomics Database, Springer – Japan, 2017, pp. 75-113. doi: 10.1007/978-4-431-56454-6_5, ISBN: 978-4-431-56454-6
25. Egorova KS, Gordeev EG and Ananikov VP. Biological Activity of Ionic Liquids and Their Application in Pharmaceutics and Medicine. Chem. Rev. 2017, 117(10): 7132–7189. doi: 10.1021/acs.chemrev.6b00562
26. Egorova KS and Ananikov VP. Toxicity of metal compounds: knowledge and myths. Organometallics 2017, 36(21): 4071–4090. doi: 10.1021/acs.organomet.7b00605
27. Kucherov FA, Egorova KS, Posvyatenko AV, Eremin DB and Ananikov VP. Investigation of cytotoxic activity of mitoxantrone at the individual cell level by using ionic-liquid-tag-enhanced mass spectrometry. Anal. Chem. 2017, 89(24): 13374-13381. doi: 10.1021/acs.analchem.7b03568
28. Galkin KI, Kucherov FA, Markov ON, Egorova KS, Posvyatenko AV and Ananikov VP. Facile access to biologically active norcantharidin derivatives from biomass. Molecules 2017, 22(12): 2210. doi: 10.3390/molecules22122210
29. Seitkalieva MM, Kashin AS, Egorova KS and Ananikov VP. Micro-scale processes occurring in ionic liquid-water phases during extraction. Sep. Purif. Technol. 2018, 196: 318-326. doi: 10.1016/j.seppur.2017.06.056
30. Seitkalieva MM, Kashin AS, Egorova KS and Ananikov VP. Ionic liquids as tunable toxicity storage media for sustainable chemical waste management. ACS Sustainable Chem. Eng. 2018, 6(1): 719-726. doi: 10.1021/acssuschemeng.7b03036
31. Egorova KS and Ananikov VP. Ionic liquids in whole-cell biocatalysis: a compromise between toxicity and efficiency. Biophys. Rev. 2018, 10: 881-900. doi: 10.1007/s12551-017-0389-9
32. Azov VA, Egorova KS, Seitkalieva MM, Kashin AS and Ananikov VP. "Solvent-in-salt" systems for design of new materials in chemistry, biology and energy research. Chem. Soc. Rev. 2018, 47: 1250-1284. doi: 10.1039/C7CS00547D
33. Egorova KS and Toukach PV. Glycoinformatics: bridging isolated islands in the sea of data. Angew. Chem. Int. Ed. 2018, 57(46): 14986-14990. doi: 10.1002/anie.201803576
34. Egorova KS and Ananikov VP. Fundamental importance of ionic interactions in the liquid phase: A review of recent studies of ionic liquids in biomedical and pharmaceutical applications. J. Mol. Liq. 2018, 272: 271-300. doi: 10.1016/j.molliq.2018.09.025
35. Egorova KS, Knirel YuA and Toukach PV. Expanding CSDB_GT glycosyltransferase database with Escherichia coli. Glycobiology 2019, 29(4): 285-287. doi: https://doi.org/10.1093/glycob/cwz006
36. Egorova KS and Ananikov VP. Biological activity of ionic liquids involving ionic and covalent binding: tunable drug development platform. In: Encyclopedia of Ionic Liquids (ed. Suojiang Zhang), Springer – Singapore, 2019. doi: 10.1007/978-981-10-6739-6_1-1
37.Egorova KS, Sinjushin AA, Posvyatenko AV, Eremin DB, Kashin AS, Galushko AS and Ananikov VP. Evaluation of phytotoxicity and cytotoxicity of industrial catalyst components (Fe, Cu, Ni, Rh and Pd): A case of lethal toxicity of a rhodium salt in terrestrial plants. Chemosphere 2019, 223: 738-747. doi: 10.1016/j.chemosphere.2019.02.043
38. Ledovskaya MS, Voronin VV, Rodygin KS, Posvyatenko AV, Egorova KS and Ananikov VP. Direct synthesis of deuterium-labeled O-, S-, N-vinyl derivatives from calcium carbide. Synthesis 2019, 51(15): 3001-3013. doi: 10.1055/s-0037-1611518
39. Egorova KS, Posvyatenko AV, Fakhrutdinov AN, Kashin AS and Ananikov VP. Assessing possible influence of structuring effects in solution on cytotoxicity of ionic liquid systems. J. Mol. Liq. 2020, 297: 111751. doi: 10.1016/j.molliq.2019.111751
40. К.С. Егорова, А.С. Дмитренок, В.П. Анаников. Токсичность ионных жидкостей. Глава в книге «Ионные жидкости: теория и практика (Проблемы химии растворов)», под ред. А.Ю. Цивадзе, Ивановский издательский дом, 2019 г., стр. 185-216, ISBN: 978-5-904580-67-4 (https://www.rfbr.ru/rffi/ru/books/o_2092972)
41. Toukach PV, Egorova KS. New features of Carbohydrate Structure Database notation (CSDB Linear), as compared to other carbohydrate notations. J. Chem. Inf. Model. 2020, 60(3): 1276-1289. doi: 10.1021/acs.jcim.9b00744
42. Egorova KS, Galushko AS, Ananikov VP. Introducing tox-Profiles of Chemical Reactions. Angew. Chem. Int. Ed. 2020, 59(50): 22296-22305. doi: 10.1002/anie.202003082
43. Egorova KS, Smirnova NS, Toukach PV. CSDB_GT, a curated glycosyltransferase database with close-to-full coverage on three most studied non-animal species. Glycobiology 2021, 31(5): 524-529. doi: 10.1093/glycob/cwaa107
44. Egorova KS, Posvyatenko AV, Fakhrutdinov AN, Galushko AS, Seitkalieva MM, Ananikov VP. Synergistic/antagonistic cytotoxic effects in mixtures of ionic liquids with doxorubicin or mitoxantrone. J. Mol. Liq. 2021, 114870. doi: 10.1016/j.molliq.2020.114870
45. Egorova KS, Posvyatenko AV, Larin SS, Ananikov VP. Ionic liquids: prospects for nucleic acid handling and delivery. Nucleic Acids Res. 2021, 49(3): 1201-1234. doi: 10.1093/nar/gkaa1280
46. Seitkalieva MM, Vavina AV, Posvyatenko AV, Egorova KS, Kashin AS, Gordeev EG, Strukova EN, Romashov LV and Ananikov VP. Biomass-derived ionic liquids based on a 5-HMF platform chemical: Synthesis, characterization, biological activity, and tunable interactions at the molecular level. ACS Sustainable Chem. Eng. 2021, 9, 9, 3552–3570. doi: 10.1021/acssuschemeng.0c08790
47. Vereshchagin AN, Frolov NA, Egorova KS, Seitkalieva MM, Ananikov VP. Quaternary ammonium compounds (QACs) and ionic liquids (ILs) as biocides: From simple antiseptics to tunable antimicrobials. Int. J. Mol. Sci. 2021, 22: 6793. doi: 10.3390/ijms22136793
48. Egorova KS, Posvyatenko AV, Ananikov VP. Synergistic/antagonistic cytotoxic effects in mixtures of ionic liquids with drugs. Eur. Biophys. J. 2021, 50 (Suppl 1), S69. doi: 10.1007/s00249-021-01558-w
49. Egorova KS, Galushko AS, Dzhemileva LU, D'yakonov VA, Ananikov VP. Building bio-Profiles for common catalytic reactions. Green Chem. 2021, 23, 6373-6391. doi: 10.1039/d1gc00207d
50. Dzhemileva LU, D'yakonov VA, Seitkalieva MM, Kulikovskaya NS, Egorova KS, Ananikov VP. A large-scale study of ionic liquids employed in chemistry and energy research to reveal cytotoxicity mechanisms and to develop a safe design guide. Green Chem. 2021, 23, 6414-6430. doi: 10.1039/d1gc01520f
51. Vavina AV, Seitkalieva MM, Posvyatenko AV, Gordeev EG, Strukova EN, Egorova KS, Ananikov VP. Merging structural frameworks of imidazolium, pyridinium, and cholinium ionic liquids with cinnamic acid to tune solution state behavior and properties. J. Mol. Liq. 2022, 352, 118673. doi: 10.1016/j.molliq.2022.118673
52. Pentsak EO, Dzhemileva LU, D'yakonov VA, Shaydullin RR, Galushko AS, Egorova KS, Ananikov VP. Comparative assessment of heterogeneous and homogeneous Suzuki-Miyaura catalytic reactions using bio-Profiles and bio-Factors. J. Organomet. Chem. 2022, 122319. doi: 10.1016/j.jorganchem.2022.122319
53. Toukach PV, Egorova KS. Source files of the Carbohydrate Structure Database: the way to sophisticated analysis of natural glycans. Sci. Data 2022, 131. doi: 10.1038/s41597-022-01186-9
54. К.С. Егорова, А.С. Галушко, Л.У. Джемилева, В.А. Дьяконов, В.П. Анаников. Использование биопрофилей реакции для анализа влияния растворителей на общую токсичность процесса C-C-сочетания. Доклады Российской академии наук. Химия, науки о материалах, 2022, т. 504, №1, стр. 49-61. doi: 10.31857/S2686953522600106 // Egorova KS, Galushko AS, Dzhemileva LU, D'yakonov VA, Ananikov VP. Application of bio-Profiles of chemical reactions for analysis of solvent impact on overall toxicity of C-C-cross-coupling process. Doklady Chemistry 2022, 504, 106-117. doi: 10.1134/S0012500822600080
55. Egorova KS, Seitkalieva MM, Kashin AS, Gordeev EG, Vavina AV, Posvyatenko AV, Ananikov VP. Biological activity, solvation properties and microstructuring of protic imidazolium ionic liquids. J. Mol. Liq. 2022, 120450. doi: 10.1016/j.molliq.2022.120450
56. Toukach PV, Egorova KS. Examining the diversity of structural motifs in fungal glycome. Comput. Struct. Biotechnol. J. 2022, 20, 5466-5476. doi: 10.1016/j.csbj.2022.09.040
57. Egorova KS, Posvyatenko AV, Galushko AS, Ananikov VP. Fast evaluation of the safety of chemical reactions using cytotoxicity potentials and bio-Strips. Chemosphere 2022, 137378. doi: 10.1016/j.chemosphere.2022.137378
Other skills and experience:
- Translator and editor (English <-> Russian, German -> Russian) in various publishing houses (Reader's Digest, 2008 – 2011; MAIK Nauka/Interperiodica, 2011 – 2013; BINOM, 2013; AST, 2005 – present; Azbooka, 2022 - present).
- Annotator (Thomson Reuters, 2011 – 2015).
Hobby:
Off-road travels, poetry, photography
