Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach

A biomass-derived platform chemical was utilized to access a demanded pharmaceutical substance with anti-HIV activity (HIV, human immunodeficiency virus) and a variety of structural analogues. Step economy in the synthesis of the drug core (single stage from cellulose) is studied including flexible variability of four structural units. The first synthesis and X-ray structure of the inhibitor of HIV-1 capsid protein assembly (CAP-1) is described.

Reference: Org. Biomol. Chem., 2016, 14, 10593-10598.

DOI: 10.1039/C6OB01731B

On-line version: http://dx.doi.org/10.1039/c6ob01731b

The research was featured on the cover of Organic & Biomolecular Chemistry Journal